Identification of Essential Functions of GRP94 in Metazoan Growth Control and Epithelial Homeostasis
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Identification of Essential Functions of GRP94 in Metazoan Growth Control and Epithelial Homeostasis by Jason Christopher Maynard Department of Cell Biology Duke University Date:_______________________ Approved: ___________________________ Dr. Christopher Nicchitta, Supervisor ___________________________ Dr. Thomas McIntosh, Chair ___________________________ Dr. Daniel Tracey ___________________________ Dr. Scott Soderling An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Cell Biology in the Graduate School of Duke University 2009
منابع مشابه
Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control.
GRP94, the endoplasmic reticulum Hsp90, is a metazoan-restricted chaperone essential for early development in mammals, yet dispensable for mammalian cell viability. This dichotomy suggests that GRP94 is required for the functional expression of secretory and/or membrane proteins that enable the integration of cells into tissues. To explore this hypothesis, we have identified the Drosophila orth...
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Esophageal cancer is a worldwide health problem with a very poor prognosis. Therefore, new diagnostic biomarkers or therapeutic strategies for identifying and managing esophageal squamous cell carcinoma (ESCC) are urgently needed. Glucose-regulated protein 94 (GRP94) is one of major endoplasmic reticulum-stress response proteins that plays a key role in cancer progression and therapeutic respon...
متن کاملEssential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway.
Increasing evidence points to a role for the protein quality control in the endoplasmic reticulum (ER) in maintaining intestinal homeostasis. However, the specific role for general ER chaperones in this process remains unknown. Herein, we report that a major ER heat shock protein grp94 interacts with MesD, a critical chaperone for the Wnt coreceptor low-density lipoprotein receptor-related prot...
متن کاملGRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.
Because only few of its client proteins are known, the physiological roles of the endoplasmic reticulum chaperone glucose-regulated protein 94 (GRP94) are poorly understood. Using targeted disruption of the murine GRP94 gene, we show that it has essential functions in embryonic development. grp94-/- embryos die on day 7 of gestation, fail to develop mesoderm, primitive streak, or proamniotic ca...
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تاریخ انتشار 2009